Synthetic Route of 109-08-0, The chemical industry reduces the impact on the environment during synthesis 109-08-0, name is 2-Methylpyrazine, I believe this compound will play a more active role in future production and life.
a) t-butyl 3-(2-pyrazinyl)propionate A solution of diisopropylamine (4.0 mL, 28.5 mmol) in THF (20 mL) was treated with 2.5M n-butyllithium (11.42 mL, 28.5 mmol) at -78° C. The mixture was warmed to RT for 0.5 h, cooled to -78° C., and 2-methylpyrazine (2.0 mL, 21.9 mmol) was added. The reaction mixture was warmed to RT, stirred for 1 h, cooled to -78° C., and butyl bromoacetate (4.25 mL, 26.3 mmol) was added. The reaction mixture was warmed to RT, stirred for 18 h and quenched with water (1 mL). The mixture was concentrated and the residue was purified by flash chromatography (silica gel, 60percent ethyl acetate/hexane) to give the title compound (3.06 g, 67percent) as a light yellow oil. MS(ES) m/e 209 [M+H]+; 1H NMR (250 MHz) delta8.37-8.57 (m, 3H), 3.10 (t, 2H), 2.74 (t, 2H), 1.43 (s, 9H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methylpyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SmithKline Beecham Corporation; US6403578; (2002); B1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem