Synthetic Route of 767340-03-4,Some common heterocyclic compound, 767340-03-4, name is (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine, molecular formula is C16H13F6N5O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of ( Z) -4-oxo-4- [3-(trif luoromethyl) -5, 6-dihydro [1,2,4] triazolo[4,3-a] pyrozin- 7 (8H) -yl] -l-(2, 4, 5-trifluorophenyl) -but-2-en-2-amine (2.00 g,4.94 mmol) and triethyl amine (1.0Og, 9.88 mmol) in dichloromethene (100 mL) was added Boc anhydride (2.15g,9.85 mmol) . The reaction mixture was stirred at reflux for40 h. Concentration was followed by purification by flash chromatography to afford 1.24 g of product (49.8percent) . 1H NMR(400 MHz, d6-DMSO) 11.27 (s, IH) 7.56-7.50 (m, IH), 5.63 (s,IH), 5.00-4.94 (m, 2H), 4.06-4.00 (m, 4H), 1.35 (s, 9H) .
The synthetic route of 767340-03-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CHIRAL QUEST, INC.; WU, Shulin; YU, Bo; WANG, Yejing; DELICE, Alain; ZHU, Jingyang; WO2010/78440; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem