Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 274-79-3, name is Imidazo[1,2-a]pyrazine, This compound has unique chemical properties. The synthetic route is as follows., category: Pyrazines
lmidazo[1 ,2-a]pyrazine (0.715 g, 6 mmol, Intermediate 1 ), 2-bromopyridine (0.644 ml_, 6.60 mmol), triphenylphosphine (0.315 g, 1.200 mmol), and palladium(ll) acetate (0.135 g, 0.600 mmol) were heated in Lambda/,Lambda/-dimethylacetamide (DMA) (8 ml.) at 150 0C for 5 hr in a microwave reactor. The bulk of the DMA was removed in vacuo and the residue partitioned between 10% isopropanol/DCM (100 ml) and saturated sodium bicarbonate solution (50 ml). Solids were removed by filtration through celite and the filtrated separated. The aqueous phase was extracted with 10% isopropanol/DCM (3 x 50 ml. The combined organic extracts were dried over anhydrous sodium sulfate and concentrated in vacuo to afford a crude oil, (2.6 g). The crude oil was partially purified by flash chromatography (Biotage SP4, 40+M, eluting with a 0-100% gradient of [(2M ammonia methanol/Ethyl acetate]/ethyl acetate) to afford material (1.59 g) which was repurified by flash chromatography (Biotage SP4, 40+M, eluting with a 0-100% gradient of [(2M ammonia methanol/Ethyl acetate]/ethyl acetate) to afford 3-(2-pyridinyl)imidazo[1 ,2-a]pyrazine (0.319 g, 1.626 mmol, 27.1 % yield).1H NMR (CDCI3, 400 MHZ) d 9.82 (dd, 1 H, J = 3.6, 1.2 Hz), 9.19 (d, 1 H, J = 1.6Hz), 8.72 (1 H, m), 8.03 (d, 1 H, J = 4.8 Hz), 7.84-7.91 m (2H), 7.29-7.21 m (2H).
According to the analysis of related databases, 274-79-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXO GROUP LIMITED; DEAN, David Kenneth; MUNOZ-MURIEDAS, Jorge; SIME, Mairi; STEADMAN, Jon Graham Anthony; THEWLIS, Rachel Elizabeth Anne; TRANI, Giancarlo; WALL, Ian David; WALTER, Daryl Simon; WO2010/125101; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem