These common heterocyclic compound, 875781-43-4, name is 2-Bromo-5H-pyrrolo[2,3-b]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 875781-43-4
A.1. Synthesis of lM-1A.1.1. Experimental procedure for the synthesis of IM-1SM-1 SM-5a IM-1a2-Bromo-5/-/-pyrrolo[2,3- 5]pyrazine SM-1 (500 mg, 2.5 mmol), 1-Boc-4-(methylamino)- piperidine SM-5a (1.082 g, 5.0 mmol), Pd2(dba)3 (139 mg, 0.1 mmol), DavePhos (238 mg, 0.6 mmol) and LiHMDS (12.625 mL, 12 mmol) are taken-up in dry THF (10 mL) and the resulting mixture is flushed with Argon and stirred for 1 h at 80 C. The reaction mixture is diluted with H20 and AcCN, Isolute is added, the solvent is removed in vacuo and the residue is purified via RP HPLC. The product containing fractions of IM-1 a (HPLC-MS method A: tRet. = 1.72 min; MS (M+H)+ = 332) are freeze dried.
The synthetic route of 2-Bromo-5H-pyrrolo[2,3-b]pyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; STADTMUELLER, Heinz; WO2012/104388; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem