Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19745-07-4, name is 2,5-Dichloropyrazine, A new synthetic method of this compound is introduced below., SDS of cas: 19745-07-4
A degazed suspension of 3,3-dimethyl-6-(2-methylpyrimidin-5-yl)indolin-2-one (100 mg, 395imol, Eq: 1.00) and 6-bromo-2,3-dimethylpyridine (88.1 mg, 474 imol, Eq: 1.20), potassium carbonate (120 mg, 869 imol, Eq: 2.20), copper(I) iodide (7.52 mg, 39.5 imol, Eq: 0.10), N,N?Dimethylethylenediamine (6.96 mg, 8.5 jil, 79.0 imol, Eq: 0.20) and acetonitrile (2 ml) was heated to 120°C for 18h.The mixture was partitioned between water (10 mL) and dichloromethane (10 mL), then theaqueous layer was extracted with dichloromethane, the combined organic layers were dried,evaporated and the residue was purified by chromatography on silica gel to give the desired compound as a white solid (73mg, 52percent). MS (mlz) = 359.2 [M + H]+ :_The title compound was prepared in analogy to Example 70 step d, with 3,3-Dimethyl-6-(2- methylpyrimidin-5-yl)indolin-2-one (example 70 step c) and 2,5-dichloropyrazine as starting materials. White solid. Yield: 6percent. MS (mlz) = 366.2 (M+H)
The synthetic route of 19745-07-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; HILPERT, Hans; KOLCZEWSKI, Sabine; HUMM, Roland; STOLL, Theodor; MUSER, Thorsten; PLANCHER, Jean-Marc; GAUFRETEAU, Delphine; (142 pag.)WO2015/197567; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem