In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 89283-32-9 as follows. Recommanded Product: 89283-32-9
[0291] To a mixture of(3-chloropyrazin-2-yl)methanol (200 mg, 1.4 mmol, 1 eq.), 1- isopropyl-5-(4,4,5,5-tetramethyl-l ,3,2-dioxaborolan-2-yl)-1H-pyrazole (393 mg, 1.67 mmol, 1.2eq.), Pd(dppf)C12 (102 mg, 0.14 mmol, 0.1 eq.), and K2C03 (580 mg, 4.2 mmol, 3 eq.) in aRB flask were added dioxane (6 mL) and water (2 mL). The mixture was heated at 100 C for 1 h, cooled to rt, filtered, concentrated, and purified on silica gel using a mixture of EtOAc and hexanes as eluent to give (3-( 1 -isopropyl- 1 H-pyrazol-5-yl)pyrazin-2-yl)methanol (110 mg, 36%) as a yellow oil. LRMS(M+H+ ] m/z 219.1.
According to the analysis of related databases, 89283-32-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLOBAL BLOOD THERAPEUTICS, INC.; CYTOKINETICS, INC.; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; METCALF, Brian; CHUANG, Chihyuan; WARRINGTON, Jeffrey; PAULVANNAN, Kumar; JACOBSON, Matthew P.; HUA, Lan; MORGAN, Bradley; WO2013/102145; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem