Application of 4858-85-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4858-85-9, name is 2,3-Dichloropyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
2,3-Dichloropyrazine (5.00 g, 33.56 mmol, 1.00 eq) was mixed with ammonia (68.27 g, 1.95 mol, 58.04 eq). The mixture was stirred at 85 C for 12 hours, concentrated under reduced pressure. The residue was purified by silica gel chromatography (column height: 250 mm, diameter: 100 mm, 100 to 200 mesh silica gel, petroleum ether / ethyl acetate = 50/1, 20/1) to deliver 3-chloropyrazine-2-amine (700.00 mg, 5.40 mmol, 16.09% yield) as a white solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,3-Dichloropyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Medshine Discovery Inc.; LUO, Wei; DING, Charles Z.; HUANG, Zhigang; CHEN, Shuhui; (162 pag.)EP3252059; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem