Adding a certain compound to certain chemical reactions, such as: 113305-94-5, name is 5-Aminopyrazine-2-carbonitrile, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 113305-94-5, Formula: C5H4N4
[000143] A solution of triphenylphosphine (5.75 g, 21.7 mmol) in anhydrous methylene chloride (35 ML) under argon at 0C was treated with N-BROMOSUCCINIMIDE (3.86 g, 21.7 MMOL). The mixture was allowed to stir for 15 min at 0C and then was treated with 3-cyclopentyl-2 (R)- (4-METHANESULFONYLPHENYL)-PROPIONIC acid (4.95 g, 16.7 mmol). The resulting mixture was then allowed to warm to 25C for 10 min. At this time, 2-AMINO-5-BROMOPYRAZINE (5.81 g, 33.4 mmol) was added, followed by the slow addition of pyridine (5.5 mL, 68.0 mmol). This mixture was allowed to stir for 3h at 25C, at which time, the reaction was concentrated in vacuo. The residue was dissolved in ethyl acetate and washed sequentially with a 1N aqueous hydrochloric acid solution (150 mL), a 10% aqueous potassium carbonate solution (100 mL), and a saturated aqueous sodium chloride solution (250 mL). The organic layer was dried over sodium sulfate, filtered, and concentrated in vacuo. Biotage chromatography (FLASH 75S, Silica, 2.5% to 5% gradient ethyl ACETATE/METHYLENE chloride) afforded 2 (R)- (4- methanesulfonyl-phenyl) -3-cyclopentyl-5-bromo-pyrazin-2-yl-propionamide (6.12 g, 81 %) as a light yellow solid.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2004/52869; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem