Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 28643-16-5, name is Methyl 3-amino-5-chloropyrazine-2-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of Methyl 3-amino-5-chloropyrazine-2-carboxylate
Acid-2: 3-Amino-5-methoxy-pyrazine-2-carboxylic acid; a) 3-Amino-5-tri-deutero-methoxy-pyrazine-2-carboxylic acid tri-deutero methyl ester; To a solution of 0.217 ml (5.33 mmol) tetra-deutero methanol in 7 ml THF was added at 0 C 94 mg (2.346 mmol) 60% sodium hydride in oil and the mixture was stirred at room temperature for 1 h. After re-cooling to 0 C 400 mg (2.132 mmol) 3-amino-5-chloro- pyrazine-2-carboxylic acid methyl ester (GB 1248146) was added and the mixture was allowed to warm to room temperature and stirred for four days.Saturated aq. NH4CI was added and the mixture was extracted with EtOAc, the combined organic layers were washed with saturated aq. sodium chloride, dried with Na2S04 and evaporated. The residue was purified by chromatography on silica gel (cyclohexane to cyclohexane/EtOAc 1 :3) to provide the title compound as colorless solid.HPLC: RtH9= 0.61 min; ESIMS [M+H]+ = 190.2;1H-NMR (400 MHz, DMSO-cfe): 5 7.51 (s, 1 H), 7.48 (br s, 2H).
According to the analysis of related databases, 28643-16-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NOVARTIS AG; HURTH, Konstanze; LUEOEND, Rainer Martin; MACHAUER, Rainer; NEUMANN, Ulf; RUEEGER, Heinrich; SCHAEFER, Michael; TINTELNOT-BLOMLEY, Marina; VEENSTRA, Siem Jacob; VOEGTLE, Markus; WO2012/95463; (2012); A1;,
Pyrazine – Wikipedia,
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