Synthetic Route of 1196152-38-1, A common heterocyclic compound, 1196152-38-1, name is 2-Bromo-5-(trifluoromethyl)pyrazine, molecular formula is C5H2BrF3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1,1 -dimethyl ethyl (lS,4S,6S)-4-ethynyl-3-azabicyclo[4.1.0]heptane-3-carboxylate D17 (150 mg), 2-bromo-5-(trifluoromethyl)pyrazine (154 mg, 0.678 mmol), DIPEA (0.592 ml, 3.39 mmol), Pd[(C6H5)3P]4 (78 mg, 0.068 mmol) and copper(I) iodide (25.8 mg, 0.136 mmol) were collected together and dissolved in DMF (5 ml).The reaction was stirred at 23 C for 3 hours.A saturated solution of NaHC03 (20 ml) was added and the aqueous layer was back extracted with Et20 (3 x 10 ml). The collected organic layers were washed with brine (3 x 5 ml), dried over Na2S04, filtered, and concentrated under vacuum to give the crude product. The crude product was purified by silica gel chromatography (SNAP KP-Sil 25g cartridge; eluted with Cy/EtOAc 5 CV from 100% Cy to 90/10, 5 CV 90/10).Evaporation of the fractions gave the title compound D18 (140 mg).UPLC (IPQC): rt = 1.38 minutes, peak observed: 312 [M+l- C(CH3)3]
The synthetic route of 1196152-38-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; DI FABIO, Romano; WO2012/89607; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem