Adding a certain compound to certain chemical reactions, such as: 312736-49-5, name is 3,5-Dichloropyrazine-2-carboxylic acid, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 312736-49-5, category: Pyrazines
To a 100 mL round-bottomed flask, 3,5-dichloropyrazine-2-carboxylic acid(3.65 g, 18.9 mmol) and NaHCO3 (4.70 g, 22.7 mmol) are dissolved in dimethylformamide (38mL). lodomethane (7.14 mL, 113 mmol) is added dropwise and the resulting mixture is stirred overnight at room temperature. The mixture is diluted in water (50 mL) and extracted with ethyl acetate (3 x 15 mL). The combined organic layers are washed with brine (4 x 10 mL), dried over anhydrous Na2504, filtered and concentrated under reduced pressure. Methyl 3,5-dichloropyrazine-2-carboxylate (3.77 g, 96%) is obtained as a yellowish solid after drying under high vacuum for 2-3 h. NMR ?H (500 MHz, CDC13) oe 8.57 (s, 1H), 4.03 (s, 3H).
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Reference:
Patent; RELAY THERAPEUTICS, INC.; D.E. SHAW RESEARCH, LLC; GIORDANETTO, Fabrizio; GREISMAN, Jack, Benjamin; MARAGAKIS, Paul; TAYLOR, Alexander, M.; DIPIETRO, Lucian, V.; KELLEY, Elizabeth, H.; LESCARBEAU, Andre; MURCKO, Mark, Andrew; PIERCE, Levi Charles, Thomas; SHORTSLEEVES, Kelley, C.; WALTERS, W., Patrick; BHAT, Sathesh; THERRIEN, Eric; DAHLGREN, Markus, Kristofer; (156 pag.)WO2018/81091; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem