Application of 889447-19-2,Some common heterocyclic compound, 889447-19-2, name is 2-Chloro-5H-pyrrolo[2,3-b]pyrazine, molecular formula is C6H4ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A 1M solution of iodine chloride in dichloromethane (4ml, 4mmol) was added dropwise to an ice-cold solution of 2-chloro-5H-pyrrolo[2,3-&]pyrazine (4) in N-methylpyrrolidone (residual from previous step) and pyridine (5ml). The reaction mixture was stirred for 60 minutes at O0C and then was concentrated in vacuo. The residue was purified by flash chromatography, using as eluent pentane/EtOAc 0% to 50%, to give the title compound (820 mg, 75% over two steps). 1Eta NMR (DMSO-d6) 8.2 (lEta,s), 8.4 (IH, s). MS(ES+): 280
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-5H-pyrrolo[2,3-b]pyrazine, its application will become more common.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2006/58074; (2006); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem