Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 313340-08-8, name is 3,5-Dichloro-6-ethylpyrazine-2-carboxamide, A new synthetic method of this compound is introduced below., Safety of 3,5-Dichloro-6-ethylpyrazine-2-carboxamide
Weighing compounds 1-3 (165 mg, 0.52 mmol), 1-4 (137 mg, 0.62 mmol) in a reaction flask, After stirring with 1,4-dioxane, N,N-diethylisopropylamine (DIPEA) (201 mg, 1.56 mmol) was added, warmed to 100 C and stirred for 12 h. After stopping the reaction, the reaction solution was cooled to room temperature, a small amount of water was added, the solid was precipitated, suction filtration, and the filter cake was rinsed with ethanol for 2 times and dried. The yellow solid product 1-5, 125 mg was obtained.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Zhang Ao; Geng Meiyu; Ye Jiqing; Ai Jing; Song Zilan; (29 pag.)CN109384774; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem