Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 290-37-9, name is Pyrazine, A new synthetic method of this compound is introduced below., COA of Formula: C4H4N2
A 250 ml round bottom flask was first placed in an ice-water bath followed by the addition of 0.01 mmol of pyrazine,0.05 mol acetaldehyde (dissolved in 15 ml of water), 15 ml of glacial acetic acid and 3 ml of concentrated sulfuric acid, stirring to completely dissolve pyrazine,And then continue to stir for 10 min, slowly dropping 0.02mmol of t-butyl hydroperoxide solution, after dripping and then continue to stir for 20 min, and finally slowly dropping the concentration of 0.02mol / L ferrous sulfate solution 1ml,After the completion of the dropwise stirring for 2 h, the mixture was filtered and washed with a large amount of water to obtain 2,5-dicarboxylic acid pyrazine.
The synthetic route of 290-37-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zhengzhou University of Light Industry; LI, XILI; ZHOU, LIMING; LI, CAIFENG; GAO, LIJUN; FANG, SHAOMING; (15 pag.)CN103896972; (2016); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem