Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5521-56-2, name is 6-Methylpyrazin-2-amine, A new synthetic method of this compound is introduced below., Formula: C5H7N3
Step 5: 5-bromo-6-methylpyrazin-2-amine A 10-L, 4-necked round-bottom flask was charged with 6-methylpyrazin-2-amine (590 g, 5.4lmol, 1.00 equiv), chloroform (7 L) and NBS (960 g, 5.39 mol, 1.29 equiv). The reaction mixture was stirred for 12 h at room temperature. The resulting solid was filtered out and the filtrate was concentrated under vacuum to give the title compound, which was used in the next step without further purification.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MERCK SHARP & DOHME CORP.; COLLETTI, Steven, L.; DEMONG, Duane; DYKSTRA, Kevin, D.; HU, Zhiyong; MILLER, Michael; (104 pag.)WO2019/99315; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem