Synthetic Route of 59303-10-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 59303-10-5 as follows.
Example 192-(2-Methyl-imidazol-1 -yl)-pyrimidine-5-carboxylic acid cvclopropyl-H -(5-methyl- pyrazin-2-yl)-pipehdin-4-vH-amideA mixture of 2-(2-methyl-imidazol-1 -yl)-pyrimidine-5-carboxylic acid cyclopropyl- piperidin-4-yl-amide (44 mg, Intermediate 20), 2-chloro-5-methylpyrazine (15 mg) and ethyldiisopropylamine (35 muIota_) in N-methyl-2-pyrrolidinone (1 .0 ml_) is heated in a microwave oven for 30 min at 200C. After removal of the solvent the residue is purified by HPLC (H2O/MeOH/TFA) to give the title compound. LC (method 3): tR = 0.92 min; Mass spectrum (ESI+): m/z = 419 [M+H]+.
According to the analysis of related databases, 59303-10-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; NEUROCRINE BIOSCIENCES, INC.; HECKEL, Armin; HIMMELSBACH, Frank; LANGKOPF, Elke; NOSSE, Bernd; ASHWEEK, Neil, J.; HARRIOTT, Nicole; WO2012/168315; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem