Electric Literature of 33332-29-5, The chemical industry reduces the impact on the environment during synthesis 33332-29-5, name is 2-Amino-5-chloropyrazine, I believe this compound will play a more active role in future production and life.
Example 776-chloro-2-[3-nitro-4-(trifluoromethyl)phenyllimidazo[1 ,2-alpyrazineA solution of 5-chloropyrazin-2-amine (0.336 g, 2.6 mmol) and 2-bromo-1 -[3-nitro-4- (trifluoromethyl)phenyl]ethanone (0.81 1 g, 2.6 mmol) in acetonitrile (15 mL) is stirred at 100 C for 18 hr. The mixture is concentrated to give the title compound (890 mg), which is used without further purification. LCMS m/z = 343.3 [M+H]+, fR = 2.65 min.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Amino-5-chloropyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PAMLICO PHARMACEUTICAL INC.; ATKINSON, Robert N.; OMMEN, Andy J.; VEAL, James M.; HUANG, Kenneth H.; SMITH, Emilie, D.; WO2012/88411; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem