Synthetic Route of 914452-71-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 914452-71-4 name is 2-Bromo-6-methylpyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of 2-bromo-6-methyl-pyrazine 53-3 (875.52 mg, 5.06mmol) and methyl 1- chloropiperidine-4-carboxylate 53-2 (1000 mg, 5.57mmoi) in toluene (25 mL) was added cesium carbonate (4.95 g, 15.18 mmol). The reaction was degassed with argon for 10 minutes. Xanthphos (146.40 mg, 253.03 umol) and Pd2(dba>3 (231.70 mg, 253.03 umol) were added and the mixture was heated at 90C for 16 hours. The reaction was then cooled to room temperature and diluted with ethyl acetate. Organic layer was washed with water and brine, dried over sodium sulfate, concentrated under reduced pressure, and purified by combiflash chromatography (eluting with 2 % methanol in dichi orom ethane) to afford methyl l-(6-methylpyrazin-2-yl)piperidine-4- carboxylate 53-4 (750 rng, 3.19 mmol, 62 99% yield) as brown solid. LC MS: ES+ 235.9.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-6-methylpyrazine, and friends who are interested can also refer to it.
Reference:
Patent; C4 THERAPEUTICS, INC.; VEITS, Gesine, Kerstin; HE, Minsheng; HENDERSON, James, A.; NASVESCHUK, Christopher, G.; PHILLIPS, Andrew, J.; GOOD, Andrew, Charles; (471 pag.)WO2019/191112; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem