Application of 875781-43-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 875781-43-4, name is 2-Bromo-5H-pyrrolo[2,3-b]pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
Bromo-7-fluoro-5H-pyrrolo [2,3-b] pyrazine preparation 2-Bromo-5H-pyrrolo [2,3-b] pyrrole (500 mg, 2.52 mmol), 1-chloromethyl-4-fluoro -1,4-monocyclo-bicyclo [2.2.2.] Octane difluoroborate (3616 (^? 1111? ‘893 11 ^, 2.52 (2 mL) and acetonitrile (6 mL). The mixture was stirred at room temperature for 2 h and then heated to 80 (TC for 48 h, then cooled to room temperature, concentrated, Purification by column & ‘ gave the title compound as an off-white solid which was used directly in the next step.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-5H-pyrrolo[2,3-b]pyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NANJING SHENGHE PHARMACEUTICAL CO., LTD.; WANG, YONG; ZHAO, LIWEN; LIU, YANG; ZHANG, JINGZHONG; WANG, DEZHONG; GAO, YIPING; CHEN, HONGYAN; ZHANG, CANG; ZHANG, DI; (68 pag.)TWI523856; (2016); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem