Adding a certain compound to certain chemical reactions, such as: 117103-53-4, name is 2-Bromo-5-nitropyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 117103-53-4, Safety of 2-Bromo-5-nitropyrazine
Example 72 2 (R)- (3-CHLORO-4-METHANESULFONYL-PHENYL)-3-CYCLOPENTYL-N- [5- (2-METHOXY- ethylamino)-pyrazin-2-yl]-propionamide [000336] A mixture of 2-bromo-5-nitropyrazine (500 mg, 2.45 mmol) and 2- METHOXYETHYLAMINE (276 mg, 3.67 mmol) in methanol (15 ML) was stirred at 25C for 5 h. After such time, the reaction was concentrated in vacuo. Biotage chromatography (FLASH 40S, Silica, 40/60 to 20/80 hexanes/ethyl acetate) afforded (2-methoxy-ethyl)- (5-nitro-pyrazin-2-yl) -amine (291 mg, 60%) as a yellow solid: mp 116.0-117. 3C ; EI- HRMS m/e calcd for C7HLON403 (M+) 198.0753, found 198. 0751.
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Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2004/52869; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem