In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C5H3ClN2O2
Intermediate 45; Ethyl 3-(5-chloropyrazin-2-yl)-3-oxopropanoate; 5-Chloropyrazine-2-carboxylic acid (Intermediate 44, 21 g, 0.132 mol) was taken in thionyl chloride (100 mL) which was heated to reflux for 2 h and excess thionyl chloride was distilled off under reduced pressure to obtain a residue, which was dissolved in dry tetrahydrofuran (100 rnL). In another round bottom flask ethyl hydrogen malonoate (15.8 g, 0.132 mol) was dissolved in tetrahydrofuran (500 rnL) which was cooled to 0 0C. To the resulting solution was added methyl magnesium bromide (88 mL, 0.265 M) and stirred the reaction mixture was stirred for 30 min before triethylamine (39.9 g, 0.396 M) was added. To this reaction mixture the above prepared acid chloride mixture was added, stirred for 2 h at room temperature and tetrahydrofuran was evaporated from the reaction mixture and the water (500 mL) was added and extracted with ethyl acetate (2 x 200 mL). The organic layers were combined and dried over anhydrous sodium sulphate, concentrated under reduced pressure to get obtain crude product which was purified by flash column chromatography (10% ethyl acetate / pet ether) to afford 16.0 g (53.16%) of ethyl 3-(5-chloropyrazin-2-yl)-3-oxopropanoate white solid. 1H NMR (400 MHz, CDClO: delta 1.26 (t, 3H), 1.28 (t, 3H), 4.18 (s, 2H), 4.20 (q, 2H), 4.30 (q, 2H), 6.28 (s, IH), 8.57 (s, IH), 8.61 (s, IH), 8.89 (s, IH), 9.04 (s, IH), 12.35 (s, IH). Mass (APCI): m/z 227 (M-H).
The synthetic route of 36070-80-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BASARAB, Gregory, Steven; HILL, Pamela; SHERER, Brian; ZHOU, Fei; WO2010/67123; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem