In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13484-56-5, name is 3-Chloro-6-methoxypyrazin-2-amine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. category: Pyrazines
Sodium hexamethyldisilazane (1M solution in THF; 0.76 ml) was added dropwise to amixture of 3-amino-2-chloro-5-methoxypyrazine (0.062 g), 4-chloro-7-(3-chloropropoxy)-3-cyano-6-methoxyquinoline (Bioorg. Med. Chem. Letters. 2000,10,2826; 0.096 g) and DMF(1.5 ml) that had been cooled to 0C. The mixture was stirred at 0C for 5 minutes and atambient temperature for 30 minutes. Acetic acid (0.023 ml) was added and the resultantmixture was evaporated. The residue was partitioned between methylene chloride and a10% aqueous sodium bicarbonate solution. The organic solution was dried over magnesiumsulphate and evaporated. The residue was triturated under diethyl ether and the resultant solidwas isolated. There was thus obtained the title compound as a solid (0.103 g); Mass Spectrum:M+lT434and436.
The synthetic route of 13484-56-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/108703; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem