Application of 55557-52-3,Some common heterocyclic compound, 55557-52-3, name is 3-Chloropyrazine-2-carbonitrile, molecular formula is C5H2ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(3) 2.78 g (7.0 mmol) of 19-2 was added to a 100 mL three-necked flask.1.12 g (8.0 mmol) of 2-chloro-3-cyanopyrazine, 78.5 mg (0.35 mmol) of palladium acetate,290 mg (0.7 mmol) of X-Phos, 2.90 g of anhydrous potassium carbonate, and three times of deaeration with nitrogen.12 mL and 6 mL of deionized water were injected, nitrogen was bubbled for 30 min, and heated at 100 C for 8 h.After the TCL monitoring reaction was completed, it was cooled to room temperature, extracted with 100 mL of dichloromethane and 200 mL of deionized water.The organic phase was washed three times with deionized water (100 mL × 3) and dried over anhydrous sodium sulfate for 10 min.After filtration and concentration, the crude product was passed through a silica gel column (5×10 cm), and the pure product was separated and dried in vacuo.Product 19 (TCzPZCN) 4.01 g was obtained in a yield of 58%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Chloropyrazine-2-carbonitrile, its application will become more common.
Reference:
Patent; Zhejiang Hongwu Technology Co., Ltd.; Ai Qi; Liu Junyuan; Duan Ke; Zhang Qisheng; (33 pag.)CN110256409; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem