Adding a certain compound to certain chemical reactions, such as: 55557-52-3, name is 3-Chloropyrazine-2-carbonitrile, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 55557-52-3, COA of Formula: C5H2ClN3
Sodium hydride (60%, 40 mg, 1 mmol, 1 eq.)Was dissolved in dry THF (3 mL)And (3,3-bismethoxy cyclobutanyl) methanol (161 mg, 1.1 mmol, 1.1 eq.)In dry THF (1 mL).The reaction solution was stirred at room temperature for 1 h,Then 3-chloropyrazine-2-carbonitrile (139 mg, 1 mmol, 1 eq.) Was added,The resulting reaction mixture was stirred at room temperature for 4 h,Then diluted with 10 mL of water,The mixture was extracted with EtOAc (15 mL x 2)The organic phase was washed with saturated sodium chloride solution,And then dried over anhydrous sodium sulfate,Then filtered,The filtrate was concentrated under reduced pressure.The residue was purified by silica gel column chromatography (eluent:PE / EtOAc (v / v) = 4/1) to give the title compound (142 mg, 54%) as a white solid.
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Reference:
Patent; East Sunshine Pharmaceutical Co., Ltd. of Guangdong; Ren, Qingyun; Luo, Huichao; Tang, Changhua; Zhang, Jiancun; Zhang, Yingjun; (30 pag.)CN104447583; (2016); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem