Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 33332-28-4, name is 2-Amino-6-chloropyrazine, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Amino-6-chloropyrazine
A solution of 2-amino-6-chloropyrazine (25g, 193.1 mmol) in MeOH (500 ml_) was treated with NBS (34.3 g, 193.1 mmol), portion-wise, over 1 hour. The resulting mixture was stirred for 16 hours thereafter. TLC analysis at this time shows a small amount of starting material remaining. Another 1.4 g NBS added and reaction heated to 50 0C for 2 hours. The mixture15 was then cooled to 38 0C and treated with NCS (25.8 g, 193.1 mmol). The reaction mixture was heated to 500C for 16 hours thereafter. The mixture was then cooled to room temperature and treated with water (500 ml_). The precipitate was collected by filtration and dried in a vacuum dessicator to afford 45.4 g (97% yield) of 2-amino-5-bromo-3,6- dichloropyrazine as a white solid: 13C NMR (75 MHz, CDCI3) delta 149.9 (s), 145.6 (s), 129.6 (s),20 121.5 (S). LCMS (15-95% gradient acetonitrile in 0.1 % TFA over 10 min), single peak retention time = 4.51 min on 30 mm column, (M+H)+ = 244, (M+H+ACN)* = 285.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MALLINCKRODT INC.; WO2007/149479; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem