Reference of 55557-52-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 55557-52-3 as follows.
Example 245-[(3-Cyanopyrazin-2-y[)amino]-N-(6-methoxypyridin-3-y[)-3-methy[- 1 ,2-thiazo[e-4-carboxamide A mixture of 5-amino-N-(6-methoxypyridin-3-y[)-3-methy[-1 ,2-thiazo[e-4-carbox- amide [Intermediate 2] (100 mg, 0.38 mmo[, 1.2 eq), 3-ch[oropyrazine-2- carbonitri[e [CAS-RN: 55557-52-3] (44 mg, 0.32 mmo[, 1.0 eq) and cesium carbonate (236 mg, 0.73 mmo[, 2.3 eq) in 3 mL dioxane/DMF (7/1) was p[aced in amicrowave via[ and f[ushed with argon. Then, pa[[adium(II) acetate (7 mg,0.03 mmo[, 0.1 eq) and Xantphos (18 mg, 0.03 mmo[, 0.1 eq) were added. The via[ was capped and the reaction mixture was stirred at an environmenta[ temperature of 110 C overnight. On coo[ing, the reaction mixture was partitioned between dich[oromethane and water. After fi[tration over Ce[ite, the organic phase wasseparated and concentrated in vacuo. The crude product was crysta[[ised from dich[oromethane/ethy[ acetate to give 30 mg (21 % yie[d of theory) of the tit[e compound in 99% purity (LC-MS area-%).UPLC-MS (Method 1): R = 1.09 mm; MS (Elneg) m/z = 366 [M-H].1H-NMR (400 MHz, DMSO-d6): oe [ppm] = 2.53 (s, 3H), 3.79 (s, 3H), 6.72 (d, 1H), 7.75(s, 1H), 8.24 (dd, 1H), 8.42 (d, 1H), 8.61 (d, 1H), 12.54 (s br, 1H).
According to the analysis of related databases, 55557-52-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BAeRFACKER, Lars; PRECHTL, Stefan; SIEMEISTER, Gerhard; WENGNER, Antje Margret; ACKERSTAFF, Jens; NOWAK-REPPEL, Katrin; BADER, Benjamin; LIENAU, Philip; STOeCKIGT, Detlef; WO2014/118186; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem