In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4858-85-9, name is 2,3-Dichloropyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 4858-85-9
59.6 g (0.40 mol) of 2,3-dichloropyrazine, 37.3 g (0.40 mol) of aniline, and 42.4 g (0.40 mol) of sodium carbonate are suspended in 250 ml of 1-methyl-pyrrolidone and heated at 151C during 24 hours. The black suspension is cooled down to 100C, filtered, and the solid residue further washed with ethyl acetate. The filtrate is concentrated under vacuum and the residual oil further purified by distillation (125-128C, 0.3 mbar) giving the title productas light yellow solid (yield: 58.3 g (71%)).1HNMR (300 MHz, CDCI3): = 7.05-7.22 (m, 2 H), 7.32-7.45 (m, 2 H), 7.57-7.68 (m, 2 H),7.75 (d, I H), 8.05 (d, H).
The synthetic route of 4858-85-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BASF SE; MURER, Peter; BATTAGLIARIN, Glauco; DORMANN, Korinna; METZ, Stefan; WAGENBLAST, Gerhard; BENEDITO, Flavio Luiz; WATANABE, Soichi; LENNARTZ, Christian; GESSNER, Thomas; WO2015/14835; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem