Synthetic Route of 486460-21-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 486460-21-3 as follows.
Anhydrous DMF and N-ethyl-N-isopropylpropan-2-amine (20.88 mg, 0.162 mmol)were added to a mixture of HATU (28.7 mg, 0.075 mmol), HOAT (10.3 mg, 0.075 mmol), 1-(6-chloro-3-cyanoquinolin-4-yl)piperidine-4-carboxylic acid (17 mg, 0.054 mmol) and 3-(trifluoromethyl)-5 ,6,7, 8-tetrahydro- [1 ,2,4jtriazolo[4,3 -aj pyrazine (12.3 mg, 0.054 mmol).The mixture was stirred at room temperature for 6 hours. The reaction mixture was pouredinto 10 ml NaHCO3 aqueous solution, and the resulting suspension was stirred for 1 hour.The mixure was filtered and the filter cake was washed with water, and dried to afford the title compound.MS: 490 (M + 1). Human CYP8B1 1C50 (nM) 23.2
According to the analysis of related databases, 486460-21-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; CUMMING, Jared, N.; DYKSTRA, Kevin, D.; HRUZA, Alan; LI, Derun; LIU, Hong; TANG, Haiqun; TAOKA, Brandon, M.; VERRAS, Andreas; WALSH, Shawn, P.; WU, Wen-Lian; (170 pag.)WO2018/34918; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem