Adding a certain compound to certain chemical reactions, such as: 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 36070-80-1, Product Details of 36070-80-1
The 5-cyclopropylmethoxy-pyrazine-2-carboxylic acid was obtained as follows:; A solution of 5-chloro-pyrazine-2-carboxylic acid (1.5 g, 9.46 mmol) in dry dimethylsulphoxide (5 ml) was treated with cyclopropyl-methanol (1.15 ml, 14.1 mmol) and powdered potassium hydroxide (2.12 g, 37.8 mmol). The mixture was irradiated in a microwave vessel at 80 C. for 45 minutes. In order to complete the transformation the irradiation was continued for another 45 minutes at 80 C. For the workup, the reaction mixture was quenched with a solution of citric acid (10%), then extracted with ethyl acetate (5×30 ml) followed by a 20:80-mixture of methanol and dichloromethane (200 ml). The combined organic layers were dried over sodium sulphate, evaporated at reduced pressure and, finally, lyophilized to remove residual dimethylsulphoxide. Further purification by flash chromatography on silica gel yielded the 5-cyclopropylmethoxy-pyrazine-2-carboxylic acid as an off-white solid (1.83 g, 27% of theory). MS (ISP): m/z=195 [M+H]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloropyrazine-2-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Banner, David; Guba, Wolfgang; Hilpert, Hans; Mauser, Harald; Mayweg, Alexander V.; Narquizian, Robert; Pinard, Emmanuel; Power, Eoin; Rogers-Evans, Mark; Woltering, Thomas; Wostl, Wolfgang; US2011/144097; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem