Application of 912773-24-1, These common heterocyclic compound, 912773-24-1, name is 6-Bromoimidazo[1,2-a]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1 : To a solution of 6-bromoimidazo [1, 2-a] pyrazine (30 g, 151 mmol) in toluene (400 mL) were sequentially added Cs2C03 (123 g, 378 mmol), 4-(ethoxycarbonyl)phenylboronic acid (35.2 g, 181 mmol) and Pd(dppf)2Cl2 (3.70 g, 4.50 mmol). The reaction mixture was stirred at 90 C for 12 h under argon atmosphere then, was filtered through celite. The filtrate was concentrated and the residue was purified the by flash column chromatography (silica gel, eluent n-hexane/EtOAc 70:30) to afford ethyl 4-(imidazo [1, 2-a]pyrazin-6-yl)benzoate (16 g, 39%) as yellow solid. 1H NMR (400 MHz, DMSO-i 6) 5: 9.35 (s, IH), 9.17 (s, IH), 8.15 (d, J= 8.4 Hz, 2H), 8.03 (d, J= 8.4 Hz, 2H), 7.88 (s, IH), 7.79 (s, IH), 4.32 (q, J= 6.8 Hz, 2H), 1.44 (t, J = 7.2 Hz 3H); MS (ESI) m/z 268 [C,5H13N302 ^H] “.
The synthetic route of 912773-24-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH; NACRO, Kassoum; DURAISWAMY, Athisayamani, Jeyaraj; CHENNAMANENI, Lohitha, Rao; WO2013/147711; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem