Application of 109-08-0, A common heterocyclic compound, 109-08-0, name is 2-Methylpyrazine, molecular formula is C5H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-methylpyrazine (2 mmol), benzyl alcohol (4 mmol, 2 equiv.), CsOH (50 mol%), 2.0 mL of toluene were sequentially added to a 100 mL reaction tube.The mixture was directly heated under air to 120 C for 24 h. The product was purified by column chromatography to give an isolated yield of 60%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Wenzhou University; Xu Qing; Li Shuangyan; Chen Jianhui; Yuan Xueqin; Zhang Zhengping; (13 pag.)CN104529889; (2018); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem