Some common heterocyclic compound, 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine, molecular formula is C7H3Cl2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 5,7-Dichloropyrido[3,4-b]pyrazine
Intermediate 29: 1,1-Dimethylethyl 3-{[(7-chloropyrido[3,4-b]pyrazin-5-yl)oxy]methyl}-4,4-difluoro-1-piperidinecarboxylate 1,1-Dimethylethyl 4,4-difluoro-3-(hydroxymethyl)-1-piperidinecarboxylate (207 mg, 0.825 mmol) was dissolved in dry N,N-dimethylformamide (DMF) (5 ml) and sodium hydride (45.0 mg, 1.125 mmol) was added under nitrogen at room temperature. After 60 min, 5,7-dichloropyrido[3,4-b]pyrazine (150 mg, 0.750 mmol) was added and the reaction was stirred at room temperature under nitrogen for 2 h. The reaction was quenched by the addition of sat. ammonium chloride solution and extracted with ethyl acetate. The aqueous layer was extracted further with ethyl acetate. The combined organics were washed with water, dried using a hydrophobic frit and evaporated in vacuo to give an orange oil (369 mg). The residue was loaded in dichloromethane and purified on silica (50 g) column using a 0-100% ethyl acetate/cyclohexane gradient. Appropriate fractions were combined and evaporated to give the title compound as an orange oil (163 mg). LCMS (Method B): Rt=1.25 min, MH+=415
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1379338-74-5, its application will become more common.
Reference:
Patent; GLAXO GROUP LIMITED; Atkinson, Francis Louis; Atkinson, Stephen John; Barker, Michael David; Douault, Clement; Garton, Neil Stuart; Liddle, John; Patel, Vipulkumar Kantibhai; Preston, Alexander G.; Shipley, Tracy Jane; Wilson, David Matthew; Watson, Robert J.; US2014/5188; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem