Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 939412-86-9, name is (3-Chloropyrazin-2-yl)methanamine hydrochloride, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 939412-86-9
To a solution of 5- (methoxycarbonyl) tricyclo [3.2.2.02, 4] nonane-1-carboxylic acid (440 mg, 1.962 mmol) in anhydrous CH2Cl2 (8 ml) was added Et3N (0.820 ml, 5.89 mmol) , (3-chloropyrazin-2-yl) methanamine, HCl (424 mg, 2.354 mmol) and HATU (895 mg, 2.354 mmol) . The reaction mixture was stirred at 15 for 12 hours. The reaction was quenched by the addtion of water (10 mL) , then it was extracted with DCM (20 mL x 3) , the combined organic layers were washed with brine (20 mL) , dried over sodium sulfate, filtered and concentrated to afford the crude product , which was purified on silica gel column chromatograph (PE /EA 100 50 ) to give methyl 5- ( ( (3-chloropyrazin-2-yl) methyl) carbamoyl) tricyclo [3.2.2.02, 4] nonane-1-carboxylate. 1H NMR (400MHz, CDCl3) delta 8.47 (d, J2.5 Hz, 1H) , 8.33 (s, 1H) , 4.70 (d, J4.8 Hz, 2H) , 3.72 (s, 3H) , 2.08 -1.83 (m, 4H) , 1.68 -1.59 (m, 4H) , 1.42 (br. s., 1H) , 1.25 (d, J7.3 Hz, 1H) , 0.84 -0.78 (m, 1H) , 0.68 -0.61 (m, 1H) ppm.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 939412-86-9.
Reference:
Patent; MERCK SHARP & DOHME CORP.; LIU, Jian; KOZLOWSKI, Joseph A.; ANDRESEN, Brain M.; BOGA, Sobhana Babu; GAO, Xiaolei; GUIADEEN, Deodialsingh; CAI, Jiaqiang; LIU, Shilan; WANG, Dahai; WU, Hao; YANG, Chundao; (111 pag.)WO2016/106624; (2016); A1;,
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