Application of 38557-72-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 38557-72-1 name is 2-Chloro-3,5-dimethylpyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Compound 1 to 86 and 89-118 in table 1 were prepared by a similar method. For compound 111, (3,5-dimethylpyrazin-2-yl)methanamine was prepared from commercially available 2-chloro-3,5-dimethyl-pyrazine via palladium-catalyzed introduction of cyanid followed by reduction to the amine using Raney Ni.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-3,5-dimethylpyrazine, and friends who are interested can also refer to it.
Reference:
Patent; H. Lundbeck A/S; SAMS, Anette Graven; RASMUSSEN, Lars Kyhn; YU, Wanwan; FLEMING, Paul Robert; (56 pag.)US2020/131156; (2020); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem