These common heterocyclic compound, 69214-33-1, name is 8-Chloroimidazo[1,2-a]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C6H4ClN3
8-chloroimidazo [1,2-a] pyrazine (1.07 g, 7 mmol) was dissolved in 15 mL glacial acetic acid, and liquid bromine (1.12 g, 7 mmol) was slowly added dropwise under an ice bath.Remove the ice bath after the addition and stir overnight at room temperature.TLC showed that the reaction was complete. Add 30 mL of saturated sodium sulfite solution and extract with ethyl acetate (30 mL * 3).The organic phases were combined and washed with 20 mL of saturated brine.Dry over anhydrous sodium sulfate, concentrate,Separation through a silica gel column gave 1.33 g of a pale yellow solid with a yield of 82%.
The synthetic route of 8-Chloroimidazo[1,2-a]pyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shenzhen Tajirui Bio-pharmaceutical Co., Ltd.; Wang Yihan; Xing Qingfeng; Ai Yixin; (85 pag.)CN110272426; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem