5521-55-1, name is 5-Methylpyrazine-2-carboxylic acid, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C6H6N2O2
Step F: N-((1S,3S,4R)-3-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-4-methylcyclopentyl)-5-methylpyrazine-2-carboxamide 5-Methylpyrazine-2-carboxylic acid (0.135 g, 0.98 mmol) was dissolved in DMF (3 mL). HATU (0.447 g, 1.17 mmol) was added and the mixture stirred at ambient temperature for about 1 min. TEA (0.6 mL, 4.30 mmol) and (1S,3S,4R)-3-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-4-methylcyclopentylamine (0.250 g, 0.98 mmol) were added and the resulting mixture was stirred at ambient temperature for about 1 h. The mixture was diluted with DCM (10 mL) and washed with a saturated aqueous solution of NaHCO3 (5 mL). The organic layer was collected, dried over MgSO4, filtered and evaporated. The resulting solid was sequentially triturated with Et2O and MeOH. The resulting solid was filtered. The filtrate was evaporated to dryness. The solid was triturated with DCM/DMF (20/1 by volume) to give a white solid that was combined with solid recovered from the Et2O/MeOH filtrate. The combined solids were triturated with EtOAc, filtered and dried to give N-((1S,3S,4R)-3-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-4-methylcyclopentyl)-5-methylpyrazine-2-carboxamide (0.164 g, 44%); LC/MS (Table 1, Method a) Rt=1.7 min; MS m/z: 376 (M+H)+. Jak3 IC50=C
The synthetic route of 5521-55-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ABBVIE INC.; Wishart, Neil; Bonafoux, Dominique F.; Frank, Kristine E.; Hobson, Adrian D.; Konopacki, Donald B.; Martinez, Gloria Y.; Wang, Lu; US2013/72470; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem