Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 486460-21-3, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine, A new synthetic method of this compound is introduced below., Computed Properties of C6H7F3N4
To adegassed solution of isopropyl (R)-2-amino-2-(4-bromophenyl)-4,4- dimethylpentanoate (57 mg, 0.017 mmol), 3-(trifluoromethyl)-5,6,7, 8-tetrahydro- [1 ,2,4jtriazolo[4,3-aj pyrazine (57 mg, 0.030 mmol), S-Phos phenethylamine chloride precatalyst (12 mg, 0.015 mol) in 1,4-dioxane (2 mL) was addedpotassium t-butoxide (57 g, 0.51 mmol). The reaction was stirred at 100C for 15 mm. The reaction mixture was cooled to rt, treated with saturated aq. ammonium chloride solution and EtOAc. The organic phase was dried over Na2SO4, filtered, concentrated down, and the residue was directly used in the next step.
The synthetic route of 486460-21-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GILEAD SCIENCES, INC.; CAI, Zhenhong R.; CHO, Aesop; BUENROSTRO, Ana Zurisadai Gonzalez; HAN, Xiaochun; JABRI, Salman Y.; MCFADDEN, Ryan; QI, Yingmei; VOIGT, Johannes; YANG, Hong; XU, Jie; XU, Lianhong; (545 pag.)WO2019/75291; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem