Application of 59489-71-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 59489-71-3, name is 2-Amino-5-bromopyrazine, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: To a solution of 2-amino-5-cyanopyridine (2b) (1190 mg, 10.0mmol) in tetrahydrofuran(100 mL), iodomethane (2.83 mL, 45.5mmol) was added andthe mixture was stirred at 0 C. The mixture was slowly addedto sodium hydride (60% in oil, 1440 mg, 36.0mmol) and stirredfor 12 h. To the reaction mixture was added methanol (20mL) to quench the reaction. Further, the reaction mixture wasdiluted with water and extracted with ethyl acetate (3 200mL). The combined organic layers were dried over Na2SO4,filtered, and the solvents were concentrated under reduced pressure.The obtained residue was purified by silica gel columnchromatography (hexane/ethyl acetate = 1/1) to yield dimethylamino 3b (1120 mg, 7.62mmol, 76%) as a dark brown solid.
The chemical industry reduces the impact on the environment during synthesis 2-Amino-5-bromopyrazine. I believe this compound will play a more active role in future production and life.
Reference:
Article; Saito, Ryohei; Kuchimaru, Takahiro; Higashi, Shoko; Lu, Shijia W.; Kiyama, Masahiro; Iwano, Satoshi; Obata, Rika; Hirano, Takashi; Kizaka-Kondoh, Shinae; Maki, Shojiro A.; Bulletin of the Chemical Society of Japan; vol. 92; 3; (2019); p. 608 – 618;,
Pyrazine – Wikipedia,
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