5521-58-4, name is 5-Methylpyrazin-2-amine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 5521-58-4
Oxalyl chloride (0.17 mL, 1.94 mmol) and DMF (1 drop) were added to a solution of 3- {[(15)-l-methyl-2-(methyloxy)ethyl]oxy}-5-[(4-methyl-5-oxo-2,3,4,5-tetrahydro-l,4- benzoxazepin-8-yl)oxy]benzoic acid (625 mg, 1.56 mmol) in DCM (15 mL) and the mixture stirred at RT for 4 hours. The solvent was evaporated in vacuo to a residue which was added to a solution of 2-amino-5-methylpyrazine (255 mg, 2.34 mmol) and pyridine (0.64 mL, 7.8 mmol) in DCM (5 mL). The resultant mixture was heated at 6O0C in a microwave reactor for 5 minutes. The mixture was cooled to RT and pressure, the DCM was evaporated in vacuo to a residue which was partitioned between ethyl acetate (50 mL) and IN citric acid (25 mL). The organic layer was washed with IN citric acid (25 mL), brine, dried (MgSO4) and evaporated in vacuo to a residue which was chromatographed on silica, eluting with ethyl acetate, to give the desired compound (352 mg).1H NMR delta (CDCl3): 1.35 (d, 3H), 2.55 (s, 3H), 3.2 (s, 3H), 3.4 (s, 3H), 3.5 (m, 2H), 3.6 (t, 2H), 4.4 (t, 2H), 4.6 (m, IH), 6.6 (d, IH), 6.8 (dd, IH), 6.85 (m, IH), 7.15 (m, IH), 7.3 (s, IH), 7.9 (d, IH), 8.1 (s, IH), 8.45 (s, IH), 9.5 (s, IH); m/z 493 (M+H)+
The synthetic route of 5521-58-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/125972; (2006); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem