5521-58-4, name is 5-Methylpyrazin-2-amine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: Pyrazines
l-Chloro-N,N.2-trimethyl-prop-l -en- 1 -amine (0.26 mL, 2.0 mmol) was added to a solution 5 of 3-[(2S)-l-(difluoromethoxy)propan-2-yl]oxy-5-phenylmethoxy-benzoic acid (0.54 g,1.5 mmol) in DCM (20 mL) and stirred for 1 hour. 5-Methylpyrazin-2-amine (ClambdaS no.5521-58-4) (335 mg, 3.1 mmol) then pyridine (0.25 mL, 3.1 mmol) were added and the reaction stirred for a further 30 minutes before being reduced in vacuo and partitioned between ethyl acetate (50 mL) and water (50 mL). The aqueous layer was further extracted K) into ethyl acetate (50 mL) and the combined organics washed with water (50 mL), brine(50 mL), dried (MgSO4), and reduced in vacuo. The crude residue was chromatographed on silica, eluting with 40-100% ethyl acetate in isohexane, to give the desired compound(0.48 g).1H NMR delta (CDCl3): 1.39 (d, 3H), 2.58 (s, 3H), 3.96 – 4.05 (m, 2H), 4.63 – 4.70 (m, IH), 15 5.13 (s, 2H), 6.30 (t, I H), 6.78 (t, IH), 7.09 (t, IH), 7.16 (t, IH), 7.35 – 7.48 (m, 5H), 8.17(s, IH), 8.39 (s, IH), 9.58 (d, IH); m/z 444 (M+H)+
The synthetic route of 5521-58-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/50117; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem