36070-75-4, name is 5-Chloropyrazine-2-carbonitrile, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: Pyrazines
A mixture of A-5 (500.00 mg, 3.58 mmol), [4- (trifluoromethoxy)phenyl]boronic acid (1.11 g, 5.37 mmol), Pd(i-Bu3P)2 (146.36 mg, 286.40 muiotaetaomicron) and K3P04 (1.52 g, 7.16 mmol) in dioxane (20 mL) and H20 (4 mL) was stirred at 80 C for 16 hours under N2. The mixture was concentrated to a residue, which was diluted with H20 (30 mL) and extracted with EtOAc (150 mL x 2). The combined organic phase was washed with water (50 mL x 2) and brine (50 mL), dried over Na2S04, filtered and concentrated to give a residue that was purified by flash chromatography on silica gel (EtOAc in PE = 5% to 10% to 15%) to give A-6 (520.00 mg, 1.96 mmol) as a solid. 1H NMR (400MHz, CDC13) = 9.14 (d, 1H), 8.96 (d, 1H), 8.16 (d, 2H), 7.41 (d, 2H).
The synthetic route of 36070-75-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PRAXIS PRECISION MEDICINES, INC.; REDDY, Kiran; MARTINEZ BOTELLA, Gabriel; GRIFFIN, Andrew, Mark; MARRON, Brian, Edward; (141 pag.)WO2018/98491; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem