59489-71-3, name is 2-Amino-5-bromopyrazine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 2-Amino-5-bromopyrazine
A mixture of 5-bromopyrazin-2-amme (2.Og, 11.56mmol) and sodium thiomethoxide(1.62g, 23.12mmol) in dry dimethyl formamide (29ml) was stirred and heated at 1000C under nitrogen for 20 hours. The solvent was removed in vacuo and the residue treated with distilled water. The aqueous solution was extracted with DCM (3 times). The organics were combined dried with anhydrous sulphate, filtered and evaporated to give the title compound as a brown solid (1.12g, 69%). NMR (CDCl3): 2.75 (s, 3H), 4.65 (s, 2H), 8.13 (s, IH), 8.2 (s, IH); m/z 142.
The synthetic route of 59489-71-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/95159; (2006); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem