Synthetic Route of 87486-34-8, A common heterocyclic compound, 87486-34-8, name is 3,5-Dibromo-1-methylpyrazin-2(1H)-one, molecular formula is C5H4Br2N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step-(iii): Synthesis of 5 -bromo- 1 -methyl-3-((3-(4-methylpiperazin- 1 -yl)phenyl)amino) pyrazin-2( 1H)-one:To a stirred solution of Intermediate-i (1 g, 3.75 mmol) in DMA (6 mL) was added compound-32b (0.78 g 4.13 mmol) and stirred at 110°C for 16h. After the reaction wascompleted, the reaction mixture was cooled to RT, poured into crushed ice; the solid formed was filtered and dried under vacuum to get the desired product (800 mg, 52percent); MS (ES) m/z 378 (M+1).
The synthetic route of 87486-34-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; BORUAH, Anima; HOSAHALLI, Subramanya; PANIGRAHI, Sunil Kumar; WO2014/125410; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem