Electric Literature of 1159811-97-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1159811-97-8 as follows.
6-Bromo-2-methylimidazo[1,2-a]pyrazine (5 g, 23.58 mmol) and sodium acetate (9.67 g, 117.9 mmol) were dissolved in acetic acid (25 mL) and water (25 mL). Aqueous formaldehyde (37%, 18 mL, 241.77 mmol) was added and the reaction mixture wasstirred at 80C for 1 h, then left to stand at room temperature for 15 h. The reaction mixture was stirred at 80C for a further 4 h, then left to stand room temperature for 15 h. The solid that formed was collected by filtration and washed with water (30 mL). A second batch of solid was obtained from the filtrate and washed with water (30 mL). A third batch of solid was obtained from the filtrate and washed with water (30 mL). Thesolids were combined and dried in vacuo to afford the title compound (4.31 g, 75.5%) as a white solid. H (500 MHz, DMSO-d6) 8.80 (d, J 1.1 Hz, 1H), 8.68 (d, J 1.2 Hz, 1H), 5.29 (t,J5.5 Hz, 1H), 4.81 (d,J5.2 Hz, 2H), 2.43 (s, 3H). LCMS m/z242.
According to the analysis of related databases, 1159811-97-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; UCB BIOPHARMA SPRL; ALEXANDER, Rikki Peter; BENTLEY, Jonathan Mark; BRACE, Gareth Neil; BROOKINGS, Daniel Christopher; CHOVATIA, Praful Tulshi; DEBOVES, Herve Jean Claude; JOHNSTONE, Craig; JONES, Elizabeth Pearl; KROEPLIEN, Boris; LECOMTE, Fabien Claude; MADDEN, James; MILLER, Craig Adrian; PORTER, John Robert; SELBY, Matthew Duncan; SHAW, Michael Alan; VAIDYA, Darshan Gunvant; YULE, Ian Andrew; WO2015/86506; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem