Synthetic Route of 5049-61-6,Some common heterocyclic compound, 5049-61-6, name is Pyrazin-2-amine, molecular formula is C4H5N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Aminopyrazine (95g, 1 mol) in chloroform (2.5 L) was cooled to between O0C and -5C. N-bromosuccimide (375 g, 2.1 mol) was then added over a 6 hour period, during which time the temperature was kept below O0C. The reaction mixture was stored in a freezer overnight and then stirred vigorously and quenched with water (1 L). The mixture was filtered through glass wool and the phases separated. The organic phase was washed with 10% K2CO3 (aq, 1 L), dried over MgSO4, and concentrated in vacuo. The residue was triturated with hexane and ethyl acetate. The yellow/brown solid was filtered and dried under high vacuum in a desiccator overnight to give the title compound (119 g). 1H (270MHz, CDCI3) 4.99 (2H, bs), 8.09(1H, s); LC-MS (AP+): 254:256 (1:1 isotopes, M+H+).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Pyrazin-2-amine, its application will become more common.
Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; WO2008/74997; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem