Reference of 186534-02-1, The chemical industry reduces the impact on the environment during synthesis 186534-02-1, name is 3,5,6-Trimethylpyrazine-2-carbaldehyde, I believe this compound will play a more active role in future production and life.
General procedure: To a stirred solution of 4-1 (0.25 mmol) in CH3OH (1.5 mL) andTHF (1.5 mL) was added compounds 5a-q (0.28 mmol) at room temperature.Keep stirring for 2-9 h to give intermediate 6a-q which wasdirectly cooled to 0 C without any treatment. Then the mixture wasadded to NaBH4 (1.25 mmol), keeping stirring for 2 h. The reaction wasquenched with 10% HCl aqueous and directly evaporated to dryness.The residue was basified with saturated NaHCO3 solution and extractedwith DCM (3 × 10 mL). Subsequently, the combined organic layerswere washed with brine (20 mL), dried over Na2SO4, filtered, concentratedand purified via column chromatograph (eluting solvent:pentane/ethyl acetate=10/1 to 4/1) to afford the desired products 7aq.Meanwhile, product 7r was obtained from compound 4-2 andcompound 5i by the same synthesis method. The yield is 47-76%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5,6-Trimethylpyrazine-2-carbaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Cao, Zhongcheng; Deng, Yong; Liu, Zhuoling; Song, Qing; Tan, Zhenghuai; Yang, Ziyi; Yu, Guangjun; Bioorganic and medicinal chemistry; (2020);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem