Reference of 1458-18-0, The chemical industry reduces the impact on the environment during synthesis 1458-18-0, name is Methyl 3-amino-5,6-dichloropyrazine-2-carboxylate, I believe this compound will play a more active role in future production and life.
Production Example 18-1 Methyl 3-amino-5,6-dimethylpyrazine-2-carboxylate A mixture of methyl 3-amino-5,6-dichloro-2-pyrazine carboxylate (200 mg, 0.90 mmol), X-Phos (170 mg, 0.36 mmol), tris(dibenzylideneacetone)dipalladium(0) (82 mg, 0.090 mmol), tetramethyltin (0.31 mL, 2.3 mmol), and N-methylpyrrolidinone (2 mL) was stirred at 130 C. for 2 hours under microwave irradiation. The reaction mixture was cooled to room temperature, water was added thereto at the same temperature, and the resulting mixture was extracted with ethyl acetate. The organic layer was washed with a saturated saline solution, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate_heptane=3:2) to obtain the title compound (80 mg, 49% yield). 1H-NMR Spectrum (400 MHz, CDCl3) delta (ppm): 2.44 (s, 3H), 2.46 (s, 3H), 3.97 (s, 3H), 6.22 (br s, 2H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-amino-5,6-dichloropyrazine-2-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Eisai R&D Management Co., Lt.d; Tanaka, Keigo; Fukuyama, Takashi; Murai, Norio; Itano, Wataru; Hirota, Shinsuke; Iida, Daisuke; Azuma, Hiroshi; (32 pag.)US2016/168176; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem