Share a compound : C6H4Br2N2O2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 3,6-dibromopyrazine-2-carboxylate, its application will become more common.

Reference of 13301-04-7,Some common heterocyclic compound, 13301-04-7, name is Methyl 3,6-dibromopyrazine-2-carboxylate, molecular formula is C6H4Br2N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General Procedures:Synthesis of compound (B) as described in the general reaction scheme; 3 ,6-dibromo-pyrazine-2- carboxylic acid.[00248] LiOH (655mg, 27mmol) is added to a solution of methyl-3-amino-2-pyrazine carboxylate (A) (J. Med. Chem. 1969, 12, 285-87) (2.7g, 9mmol) in THF:water:MeOH (18:4.5:4.5mL).The reaction is stirred at 50C for 30min, concentrated in vacuo, taken up in DCM and washed with IN HCl. The organic phase is dried over MgSO4 and concentrated in vacuo to afford compound (B). 1H NMR (250MHz, CDCl3) delta(ppm)8.70(lH, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 3,6-dibromopyrazine-2-carboxylate, its application will become more common.

Reference:
Patent; GALAPAGOS N.V.; WO2007/131991; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem