Adding a certain compound to certain chemical reactions, such as: 6863-73-6, name is 3-Chloropyrazin-2-amine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6863-73-6, HPLC of Formula: C4H4ClN3
2-Amino-3-chloropyrazine 9 (10.0 g, 77.2 mmol) was added to a stirred suspension of NCS (11.6 g, 86.9 mmol) in chloroform (73 mL). The reaction mixture was heated at reflux for 4 h. The solution was cooled and partitioned between chloroform (180 mL) and water (2*50 mL). The organic layer was dried, filtered and concentrated. Flash chromatography on silica, eluting with chloroform, gave 10 (9.66 g, 76%) as a pale yellow solid. Mp 200-202 C; Rf (CHCl3) 0.32; numax (thin film/cm-1) 3411 (NH2), 3019 (Ar CH); (found: C, 28.89; H, 1.71; N, 24.99; C4H3N3Cl2: 0.125(H2O) requires C, 28.90; H, 1.97; N, 25.28%); deltaH (500 MHz; CDCl3) 4.96 (2H, br s, NH2), 7.90 (1H, s, 6-H); deltaC (125 MHz; CDCl3) 131.4, 134.6, 140.0, 150.3; GC-MS m/z 167, 165, 163 (M+), GC tR 2.51 min; purity 98%; HRMS (found: MH+ m/z 163.9782; requires 163.9777).
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Reference:
Article; Caldwell, John J.; Veillard, Nicolas; Collins, Ian; Tetrahedron; vol. 68; 47; (2012); p. 9713 – 9728,16;; ; Article; Caldwell, John J.; Veillard, Nicolas; Collins, Ian; Tetrahedron; vol. 68; 47; (2012); p. 9713 – 9728;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem