In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 22047-25-2, name is Acetylpyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 22047-25-2
A solution of acetylpyrazine (5 g, 40.9 mmol) in N, N-dimethylformamide dimethyl acetal (10.9 mL, 81.8 mmol) and Et3N (5.7 mL) was heated at 110C for 16 h. The heating was stopped and a precipitate was formed while it was allowed to cool down to room temperature. The suspension was diluted with tert-butyl methyl ether; the solid was separated by filtration and washed with ter-butyl methyl ether. This material was triturated with the same solvent, filtered off and dried to afford the title compound 23a as a yellow solid (5.9 g, 33.3 mmol, 81% yield).’H NMR (400 MHz, DMSO-d6) 8 (ppm): 9.09 (s, 1H), 8.73 (d, J = 2.4 Hz, 1H), 8.66 (dd, J = 2.4, 1.6 Hz, 1H), 7.84 (d, J = 12.4 Hz, 1H), 6.30-6. 20 (m, 1H), 3.19 (s, 3H), 2.93 (s, 3H).
The synthetic route of 22047-25-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; METHYLGENE INC.; WO2005/92899; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem